Axitinib Tablets Price - Manufacturers & Suppliers

Axitinib Tablets

API: Axitinib
Packaging: Tablets
Strength: 1 MG and 5 MG

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Description

Introduction to Axitinib Tablets

Uses of Medicine: Axitinib tablets 1 mg and 5 mg is a kinase inhibitor. Patients, Healthcare Professionals, or Hospitals can buy Axitinib 1 mg/5 mg Tablets online from India through Indian Generic Medicines (a trusted Axitinib tablets Supplier, Exporter, and Contract Manufacturer in India) for the management and treatment of advanced kidney cancer, which is also known as renal cell carcinoma that originates in the cells of the kidney. Axitinib tablets is used:

  • In combination with the medicine avelumab, for the first-line treatment of patients with advanced renal cell carcinoma (RCC).
  • In combination with the medicine pembrolizumab, for the first-line treatment of patients with advanced renal cell carcinoma (RCC).
  • As a single agent, for the treatment of advanced renal cell carcinoma (RCC) after failure of one prior systemic therapy.

Axitinib tablets can result in a greater bleeding tendency which renders surgical and dental work while on treatment unsafe. Make sure to disclose any dental or medical procedures to the physician beforehand. Avalosar does need to be taken with safe medical guidance as non-compliance may result in adverse consequences. On the other hand, severe side effects such as intense itching, change in vision, confusion, and dizziness should be attended to urgently. Side effects which include mouth ulcers, sudden loss in weight, and skin rashes should also never be ignored and be presented to the physician as soon as possible.

This oral drug can cause harm to an unborn baby. So, if you are pregnant or planning to have a baby, talk to your clinician before starting therapy. Both males and females must consider apt contraception during treatment and for at least 7 days after the final dose to prevent pregnancy. Mothers are advised to avoid breastfeeding during treatment, as it may pass into breast milk and impact the growth and development of the fetus. To ensure safety, always follow your clinician’s guidance and discuss any concerns regarding family planning while on this medicine.

Children and teenagers aged under 18 years should not take this oral drug, as it is not recommended for young patients. While on treatment, your clinician may conduct regular blood tests to check your white blood cell counts, platelets, blood sugar levels, electrolytes, and kidney function to prevent serious complications. In some cases, gastrointestinal issues such as nausea, diarrhea, vomiting, or constipation may occur.

In such cases, report to a doctor immediately. If you experience symptoms like shortness of breath, chest pain, or a worsening cough, seek medical help quickly. Always keep in contact with your healthcare provider (HCP) and report any unusual side effects to ensure a safe and smooth treatment journey.

Dosage & Side Effects

First-Line Advanced RCC:

  • Axitinib in Combination with Avelumab: The recommended starting dosage of Axitinib is 5 mg orally taken twice daily (12 hours apart) with or without food along with avelumab 800 mg administered as an IV infusion over 60 minutes every 2 weeks until there is evidence of disease progression or unacceptable toxicity. When Axitinib is used along with avelumab, dose escalation above the initial 5 mg dose may be considered at intervals of 2 weeks or longer.
  • Axitinib in Combination with Pembrolizumab: The recommended starting dosage of Axitinib is 5 mg orally twice daily (12 hours apart) with or without food along with pembrolizumab 200 mg every 3 weeks or 400 mg every 6 weeks administered as an IV infusion over 30 minutes until there is evidence of disease progression or unacceptable toxicity. When Axitinib is used along with pembrolizumab, dose escalation above the initial 5 mg dose may be considered at intervals of 6 weeks or longer.

Second-Line Advanced RCC: When Axitinib is used as a single agent, the recommended starting oral dose is 5 mg twice daily. Administer Axitinib doses approximately 12 hours apart with or without food.

The most commonly reported side effects of Axitinib 1 mg/5 mg may vary depending on its use along with other medicines: Side effects of Axitinib:

  • In combination with avelumab: fatigue, diarrhea, hypertension, decreased appetite, abdominal pain, dyspnea, rash musculoskeletal pain, nausea, mucositis, palmar-plantar erythrodysesthesia, dysphonia, hypothyroidism,, hepatotoxicity, cough, and headache.
  • In combination with pembrolizumab: diarrhea, fatigue/asthenia, hypertension, hepatotoxicity, palmar-plantar erythrodysesthesia, hypothyroidism, decreased appetite, nausea, constipation, stomatitis/mucosal inflammation, dysphonia, rash, and cough.
  • As a single agent: fatigue, diarrhea, hypertension, decreased appetite, nausea, dysphonia, weight decrease, vomiting, palmar-plantar erythrodysesthesia (hand-foot) syndrome, asthenia, and constipation.

Warning and Precautions

  • Hypertensive disorder, including a hypertensive crisis, was noted. Blood pressure must be monitored and controlled prior to starting Axitinib. They require ongoing evaluation and treatment. Manage the hypertension by moderating, discontinuing, or lowering the dose of Axitinib as warranted by the patient’s condition.
  • Fatal arterial and venous thromboembolic events may develop. Use this medicine with a lot of caution in high-risk individuals. Permanently stop treatment if an arterial thromboembolic event occurs. For venous thromboembolism, withhold and either resume at the same dose or permanently stop based on severity.
  • Fatal and non-fatal hemorrhagic events have been documented. Axitinib 1 mg/5 mg is qualitatively contraindicated in patients with actively bleeding gastrointestinal organs or untreated brain metastasis. The dosage should be reduced or stopped depending on the severity of the remaining and ongoing bleeding events.
  • Potentially lethal cardiac failure has been documented. Patients should be watched for cardiac signs and symptoms during therapy. In terms of more severe cardiac failure, management may require dose reduction, cessation, or withholding of Axitinib treatment altogether.
  • Gastrointestinal perforation and fistula, which include cases of death are among some of the newly reported adverse events. Use should be restricted in such high-risk patients. Complications arising from this should be closely observed and appropriate corrective action taken as necessary.
  • Cases have been documented that noted hypothyroidism along with hypothyroidism that needed the replacement of the thyroid hormone. While using Axitinib, there is a need to assess the patient’s thyroid function both before the drug is given and periodically during the course of treatment. Effective management of thyroid-associated adverse events may need changes in treatment approaches.
  • For elective surgeries, this medicine must be stopped at least two days prior. After conducting major surgery, the medication should not be resumed for a minimum of two weeks or until the patient’s wound is fully healed. Creating a control group or stopping the treatment should be applied in regards to of wound healing complications and their severity and how long they last.
  • During treatment, RPLS has been noted. Headaches, confusion, seizures, and vision blurring are some of the symptoms. If RPLS is confirmed, Axitinib use should be stopped immediately. Drastic measures should be taken to treat the symptoms as fast as possible, in order to keep the patient safe and out of danger.
  • Before treatment with this medicine is started, and then periodically, monitor for proteinuria. If proteinuria is diagnosed as being moderate to severe, stop using Axitinib altogether, and lessen the use of other prescribed medications before recaning normal dosages. Consistent checkups allow for immediate management if renal issues arise.
  • Considering the use of avelumab or pembrolizumab can cause a rise in the levels of liver enzymes. Keep a close eye on ALT, AST, and bilirubin levels. Note that constant supervision, steroid medications, and permanent treatment cessation are needed when in the presence of severe and extreme harm to the liver.
  • Patients who suffer from moderate hepatic impairment or other sorts of imbalances should be cautioned while using Axitinib, the starting dosage should be less. This drug has not been evaluated in such patients, so its use in such patients is unclear and remains to clinical judgment.
  • The combination of Axitinib with Avelumab may be associated with an increased risk of major cardiovascular events. Management of cardiovascular risk factors should be optimized prior to starting treatment. For severe Grade 3-4 events, Axitinib should be discontinued permanently to ensure against life-threatening scenarios.
  • This oral therapeutic drug may cause fetal harm. Advise patients on the potential risks and recommend effective contraception during treatment. Counsel pregnant patients or patients who intend to get pregnant about other treatment options to minimize fetal exposure.

FAQ's

What is Axitinib?

Axitinib is an anticancer drug that belongs to the class of tyrosine kinase inhibitors. It is used to treat advanced kidney cancer, which is also known as renal cell carcinoma that originates in the cells of the kidney.

How are Axitinib 1 mg and 5 mg Tablets administered?

Axitinib 1 mg/5 mg tablets are administered orally, twice daily, with or without food. Swallow tablet whole with water, at consistent intervals, as prescribed by the healthcare provider (HCP).

How should I store Axitinib 1 mg and 5 mg Tablets?

Store Axitinib 1 mg and 5 mg oral tablets at 20 to 25°C (68 to 77°F), with permissible excursions between 15 to 30°C (59 to 86°F). Keep in a dry place, away from moisture.

How much does the Axitinib 1 mg and 5 mg Tablet cost in India?

Axitinib 1 mg and 5 mg Tablets are available in India at competitive and reasonable prices, though the cost may vary depending on the supplier and location. For those looking to buy Axitinib online legally and without hassle, Indian Generic Medicines (IGM) offers an easy and reliable solution. To inquire about the current Axitinib 1 mg/5 mg price in India, simply call us at +91 8130290915 or dial our TOLL-FREE Number 1800-889-1064. You can also email us at info@indiangenericmedicines.com for detailed pricing information and assistance.

Where can I get Axitinib 1 mg and 5 mg Tablets at the best price?

To ensure you receive Axitinib at the most competitive price, kindly reach out to Indian Generic Medicines (IGM) today. We are committed to offering the best prices for Axitinib from India. We can match or beat the cost offered by other suppliers or distributors in the market. Contact us via Call/WhatsApp at +91 8130290915, or use our TOLL-FREE Number 1800-889-1064. Alternatively, you can email us at info@indiangenericmedicines.com. Please note that a valid medical prescription is required to purchase an Axitinib tablet.

Are Axitinib 1 mg and 5 mg Tablets available in India?

Yes, Axitinib 1 mg and 5 mg Tablets are available in India as a prescription medication. This oral pharmaceutical drug can be legally obtained through India’s authorized distributor network, which spans major cities such as Hyderabad, Mumbai, Bangalore, Ahmedabad, Delhi, Kolkata, Chennai, and Pune. To buy generic Axitinib online from India, a valid prescription from a healthcare professional (HCP) is required. Indian Generic Medicines (IGM) can assist you in sourcing generic Axitinib from India’s top suppliers.

Can you send Generic Axitinib 1 mg and 5 mg Tablets to foreign destinations?

Indian Generic Medicines (IGM) specializes in the export and delivery of generic Axitinib 1 mg and 5 mg Tablets at the lowest prices. We facilitate the shipment of Axitinib tablets to various countries, including but not limited to UAE, Australia, the USA, Saudi Arabia, Canada, the UK, Germany, France, Belgium, Bulgaria, Brazil, Kenya, Japan, and South Africa. Whether you are located in Australia, North America, South America, Eastern Europe, Western Europe, the Middle East, Africa, Central America, or Asia, IGM can assist in delivering generic Axitinib as per your requirements. For more information on international shipping options, contact us today.

What Is the procedure for buying Axitinib 1 mg and 5 mg Tablets from Indian Generic Medicines?

To buy Axitinib tablets online from India through Indian Generic Medicines (IGM), patients need to fill out the order form or send an email to info@indiangenericmedicines.com. Alternatively, you can send a WhatsApp message to +91 8130290915 or call our TOLL-FREE Number 1800-889-1064. After receiving your inquiry, we will provide you with the details regarding the Axitinib 1 mg and 5 mg price in India and the procurement procedure. Please note that your order will only be confirmed once we receive a valid prescription from your physician.

Is it safe to buy Axitinib 1 mg and 5 mg Tablets online from India?

Yes, buying Axitinib tablets online from India through Indian Generic Medicines (IGM) is safe, especially if the drug is not registered or unavailable in your country. IGM facilitates the legal export of Axitinib 1 mg and 5 mg Tablets to various countries. We ensure that you get genuine therapeutic drugs at the best price. Our service ensures compliance with all necessary regulations, providing a secure and reliable way to access generic Axitinib from India.

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