Trientine Hydrochloride 250mg Capsules - Triokris

Trientine Hydrochloride 250 mg Capsules

  • Brand Name: Triokris
  • API: Trientine Hydrochloride USP
  • Packaging: 100 Capsules per Bottle
  • Strength: 250 mg
  • Manufacturer: Ikris Pharma Network Pvt. Ltd. (Manufactured in a US FDA–approved facility)
  • Therapeutic Area: Wilson’s Disease
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Description

Introduction to Trientine Hydrochloride 250mg Capsules

Trientine Hydrochloride 250 mg Capsules (brand name: Triokris) are a high-quality medicine used to help remove excess copper from the body in patients with Wilson’s disease, a rare inherited liver and neurological condition. Manufactured by Ikris Pharma Network Pvt. Ltd. in a US FDA-approved facility, these capsules meet strict international quality and safety standards. Through Indian Generic Medicines (IGM), we supply and export Trientine Hydrochloride Capsules to countries such as Brazil, Turkey, Malaysia, Slovakia, the UAE, and Romania, ensuring global access to effective Wilson’s disease treatment. Trientine 250 mg works by binding to copper and helping the body eliminate it naturally, making it suitable for patients who cannot tolerate penicillamine. As a CDSCO-approved and trusted global exporter, IGM provides affordable and genuine generic Trientine Hydrochloride Capsules for hospitals, NGOs, and government healthcare programs worldwide.

Dosage & Side Effects

The recommended dosage of Trientine Hydrochloride for adults and adolescents typically ranges between 750 mg and 1500 mg/day, administered in two to four divided doses. The medicine is taken on an empty stomach, at least one hour before or two hours after meals, to optimize absorption. Avoid the concomitant use with iron, zinc, calcium, or magnesium supplements, as these may interfere with drug absorption. Dosage adjustments must be made under medical supervision, depending on clinical response, laboratory monitoring, and individual patient requirements. Therapy should always be started and managed by a qualified healthcare professional.

The most commonly reported side effects of Trientine Hydrochloride 250 capsules are abdominal pain, change of bowel movements, rash, alopecia, mood swings, difficulty in moving, muscle pain, iron deficiency anemia, and hypersensitivity skin reactions.

Warning and Precautions

  • Do not use Trientine Capsules if you are allergic to this medicine or any other components. Continuous medical supervision is required throughout treatment to ensure safety, monitor for side effects, and manage copper levels effectively in those with Wilson’s Disease.
  • Constant medical oversight during therapy is critical. Regular blood tests are needed to monitor free copper concentration, iron levels, and overall treatment response, particularly in women, to avoid iron deficiency anemia and ensure safe, effective disease management.
  • Trientine Capsule acts as a chelating agent that may reduce serum iron levels. In some cases, iron supplementation becomes necessary. When taking oral iron, it should be administered separately—at least two hours apart—to prevent interference with Trientine absorption and activity.
  • Concurrent use of Trientine Capsules with zinc is not recommended due to insufficient clinical data on their combined safety and dosage. Limited research prevents establishing appropriate dosage guidelines; therefore, physicians typically advise avoiding simultaneous administration to maintain consistent therapeutic efficacy.
  • Patients who previously received D-Penicillamine have reported lupus-like symptoms after switching to Trientine 250 mg Capsules. However, a direct cause-and-effect relationship remains unclear. Physicians should monitor such patients closely during early therapy to detect any immune-related complications.
  • For patients with hepatic or renal impairment, consistent monitoring is important during treatment with Trientine (Tryprine). Regular assessment of liver enzymes, kidney function, and copper balance helps maintain treatment safety and optimize dosage while preventing potential toxicity or metabolic complications.

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