Paxlovid is a combination of Nirmatrelvir, an antiviral medication, which is designed to stop the virus from spreading into the body, and medicine Ritonavir, which works like a booster that increases the existence of Nirmatrelvir in the body to enhance the effectiveness of this combination medication.
The FDA has authorized the emergency use of Paxlovid to treat mild-to-moderate COVID-19 in adults and children (aged 12 years and older, weighing at least 40kg), with a positive test for SARS-CoV 2, who are at risk for progression to disease including hospital stay and death.
Also the medicine is only indicated withing 5 days of the onset of signs/symptoms of Coronavirus disease (COVID-19).
The FDA-approved COVID-19 medicine had demonstrated 89% efficacy in phase 2 & 3 clinical trials when given within 3 days of symptoms, and as per an US study it reduced hospital stay or death by 49% in a highly vaccinated group of individuals of beyond 50 years of age.
Notably, the clinical trials of medicine has demonstrated that it works effectively in vaccinated people, too, as 90.3% of people in the US study had 3 or more vaccine doses. It may be significant for a small group of those who get infected and may develop severe complications, despite a very high COVID-19 coverage in India.
Dosage, Strength and Administration:
Nirmatrelvir supplied as 150mg tablets ritonavir is supplied as 100mg tablets. A single Paxlovid dose is:
- 2 Nirmatrelvir tablets
- 1 Ritonavir tablet
A single dose (2 tablets of Nirmatrelvir and 1 tablet of Ritonavir) twice daily for 5 consecutive days. It is absolutely necessary to start taking treatment within 5 days of getting COVID-19 symptoms. The pills should be swallowed whole with a water. It is not advisable to crush, chew or break the pills. Tablets may be taken with or without meal.
Take a single dose of 3 pills in the morning and a single dose of 3 tablets in the evening for consecutive days. Maintain a time-span of 12 hours between morning and evening dose.
Side Effects from Nirmatrelvir and Ritonavir:
Most individuals who take this medicine not experience any side effects. This combination medicine for COVID-19 is well-tolerated. But individuals should stop taking Nirmatrelvir and Ritonavir and call a health specialist right away in case they experience any of the below listed signs of allergic reactions:
- Hives
- skin rash
- hoarseness
- Throat tightness
- trouble swallowing or breathing
- swelling of the mouth, lips, or face
Other probable side effects may include: nausea, diarrhea, muscle aches, abdominal pain, feeling generally unwell, increased blood pressure, and an altered or impaired sense of taste.
Paxlovid and Its Efficacy Against All Variants of COVID-19:
Paxlovid has seeken much attention across the globe over the last several months as it demonstrated efficacy and promising outcomes against all variants of SARS CoV 2, including Omicron variant and its different sub-variants which have shown immune escape features and are capable of cursing repetitive infection.
The antiviral medicine is useful across all variants of COVID-19. It is effective for all those who have risk factors for developing severe disease. The antiviral medicine Paxlovid reduced the risk of hospital stay or death from SARS-CoV-2 Omicron variants in older individuals by 44%.
According to Dr Gagandeep Kang, a virologist and who teaches at the Christian Medical College, Vellore, “As the virus has evolved to escape immunity, the monoclonal antibody therapies no longer work.” So, Paxlovid is the only significant antiviral we have, since medicine Molnupiravir (another drug widely used for COVID-19 disease) seems to be not as much as good and has a few safety concerns.
Availability in India:
Not only people from India, but people from all over the world can hope to access Nirmatrelvir and Ritonavir. IKRIS Pharma Network can supply the generic version of Paxlovid (Nirmatrelvir/Ritonavir) across the globe including low- and middle-income countries.
Make an inquiry and we will help you calculate the total price to buy Nirmatrelvir and Ritonavir online and have it delivered to your location. From your side, we’ll simply need a valid prescription from your treating physician. The team of IKRIS will guide you throughout the process. Kindly get in touch with us today either via TOLL-FREE: 1800-889-1064, or Email: info@ikrispharmanetwork.com, or WhatsApp: +91 8130290915.
Reference:
https://www.yalemedicine.org/news/13-things-to-know-paxlovid-covid-19
https://www.nih.gov/news-events/nih-research-matters/paxlovid-reduces-serious-risks-omicron-variants
